Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

Authors Chen Z, Guo X, Tao R, et al. and Zheng W.
Citation Cancer Prev Res (Phila). 2025 May 15.
PubMed Link https://pubmed.ncbi.nlm.nih.gov/38670944/
PMCID PMC11053150

Adenomas from individuals with pathogenic biallelic variants in the MUTYH and NTHL1 genes demonstrate base excision repair tumour mutational signature profiles similar to colorectal cancers, expanding potential diagnostic and variant classification applications

Adenomas from individuals with pathogenic biallelic variants in the MUTYH and NTHL1 genes demonstrate base excision repair tumour mutational signature profiles similar to colorectal cancers, expanding potential diagnostic and variant classification applications

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